乱伦秀

Programme

09:30 鈥� 09:40听Welcome and an Introduction to the 乱伦秀 QS MND Centre:听Andrea Malaspina, Clinical Academic Lead for MND, 乱伦秀 Queen Square

Session 1: Genetic Technologies

09:40 鈥� 10:00听Jan Veldink, University Medical Center Utrecht / UMC Utrecht Brain Center, Netherlands -听Project MinE: the rare variant architecture of ALS in 2024
10:00 鈥� 10:20听Eran Hornstein, Department of Molecular Neuroscience, Weizmann Institute of Science, Israel -听miRNA in ALS
10:20 鈥� 10:40听Clotilde Lagier-Tourenne, Massachusetts General Hospital/Harvard Medical School -听Combining genetic and pharmacological screens to identify new therapeutic targets in ALS
10:40 鈥� 11:00 Coffee Break
11:00 鈥� 11:20听Oscar Wilkins, 乱伦秀 Queen Square Institute of Neurology -听New Technologies for Gene Therapies in ALS
11:20 鈥� 11:40听Andrew Bassett, Wellcome Sanger Institute -听A CRISPR approach to studying neurodegenerative disease

Session 2: Proteins, Lipidomics and Metabolism

11:40 鈥� 12:00听Tammaryn Lashley, 乱伦秀 Queen Square Institute of Neurology -听New Pathologies in ALS and FTD
12:00 鈥� 12:20听Benjamin Ryskeldi-Falcon, MRC Laboratory of Molecular Biology, University of Cambridge -听Atomic pathology of ALS and FTD by cryo-EM of amyloid filaments
12:20 鈥� 12:40听Adrian Isaacs, 乱伦秀 Queen Square Institute of Neurology -听Insights from lipidomic approaches in ALS
12:40 鈥� 13:00听Luc Dupuis, University of Strasbourg [Virtual] -听FUS: a broad role in muscle and vulnerable neurons in neuromuscular diseases
13:00 鈥� 14:00 Lunch Break

Session 3: Immune System

14:00 鈥� 14:20听Sian Henson, William Harvey Research Institute 鈥� Queen Mary University of London -听Immune senescence and ALS
14:20 鈥� 14:40听Albert La Spada, University of California Irvine School of Medicine -听Delineating Novel Pathways of Motor Neuron Demise in ALS
14:40 鈥� 15:10听KEYNOTE:听Steven Finkbeiner, Center for Systems and Therapeutics & Taube/Koret Center for Neurodegenerative Disease, Gladstone Institutes, University of California, San Francisco -听AI and ALS: from image analysis to 鈥渢hinking鈥� microscopy
15:10 鈥� 15:40 Tea Break

Session 4: AI and Big Data

15:40 鈥� 16:00听Jon Rohrer, 乱伦秀 Queen Square Institute of Neurology -听Digital and remote biomarkers in ALS/FTD
16:00 鈥� 16:20听Orla Hardiman, Trinity Biomedical Sciences Institute, Trinity College Dublin -听PRECISION ALS
16:20 鈥� 16:40听James Cole, University College London, Department of Computer Science -听Machine learning for multivariate prognostic models in MND

16:40 鈥� 16:50 10-minute comfort break

16:50 鈥� 17:10听Clive Svendsen, Cedars Sinai, Medical Center, California [Virtual] -听Using Answer ALS and organ chip models to revel specific deficits in iPSC derived motor neurons
17:10 鈥� 17:20听Ben Cryar, Principal Analyst Opportunity Assessment Group, LifeArc -听LifeArc鈥檚 Vision for Data & AI in ALS Research
17:20 鈥� 17:40听Bethan Kilpatrick, BenevolentAI -听AI augmented target identification in ALS, taking a disease mechanism approach, exemplified听by our most advanced drug discovery programme
17:40 鈥� 17:50听Closing Remarks听鈥撎�Linda Greensmith, Scientific Lead for NMD, 乱伦秀 Queen Square and听Ammar Al-Chalabi, Co-Director, UK MND Research Institute

Fifth 乱伦秀 Queen Square Motor Neuron Disease Centre International Symposium has been approved by the Federation of the Royal Colleges of Physicians of the United Kingdom for 6 category 1 (external) CPD credit(s)